Rob Beagrie

Oxford, UK
Twitter: @RobBeagrie
Github: rbeagrie

Summary

I'm a Postdoctoral Scientist working in Prof. Doug Higgs' lab at the MRC Weatherall Institute for Molecular Medicine in Oxford (rdm.ox.ac.uk/people/doug-higgs). I work on both wet-lab and bioinformatics projects, with a major interest in cis-regulatory elements in mammalian genomes. I'm especially fascinated by the regulation of gene expression by 3D chromatin folding, and the mechanisms of enhancer action.

Research

Sir Henry Wellcome Postdoctoral Fellowship

MRC Weatherall Institute, Oxford, UK & UMass Medical School, Worcester, USA

(Apr 2018 - Current)

Postdoctoral Scientist

MRC Weatherall Institute of Molecular Medicine, Oxford

(Nov 2016 - Mar 2018)

  • Working on enhancer function in early erythropoieis in Prof. Doug Higgs' laboratory

Postdoctoral Scientist

Berlin Institute for Medical Systems Biology, Berlin

(Aug 2015 - Nov 2016)

  • Working on chromatin folding and nuclear organization in Prof. Ana Pombo's laboratory

MRC Funded PhD Studentship

MRC Clinical Sciences Centre, London

(Oct 2011 - Jul 2015)

  • Implemented and applied Genome Architecture Mapping (GAM) to study chromatin folding in mouse embryonic stem cells
  • Co-supervised by Prof. Ana Pombo (MDC) and Prof. Niall Dillon (CSC)

Research Assistant

Department of Biochemistry, Cambridge University

(Oct 2010 - Aug 2011)

  • Studied C. crescentus polynucleotide phosphorylase in Prof. Ben Luisi’s group
  • Cloning, expression, protein affinity purification, enzymatic assays and crystallography

Cancer Research UK Summer Studentship

CRUK London Research Institute, London (Holborn)

(Jun 2010 - Sep 2010)

  • Studied Polycomb group proteins and their interaction with the ncRNA HOTAIR with Dr. Gordon Peters
  • Chromatin Immunoprecipitation, qPCR, lentiviral shRNA knockdowns, qRT-PCR and western blotting

Research Assistant

Department of Biochemistry, Cambridge University

(Jan 2010 - May 2010)

  • Development of the NMR analysis tool “DANGLE” with Dr. William Broadhurst
  • Programming, data analysis and statistical work to improve the accuracy of the DANGLE algorithm for predicting protein dihedral angles from chemical shift data

Work Experience Student

Wellcome Trust Sanger Centre, Hinxton

(Jun 2005 - Jun 2005)

  • 1 week placement with an ENCODE project group
  • 1 week placement in the sequencing centre

Awards and Fellowships

Best Long Talk

Quantitative Genomics 2016, London, UK

(Apr 2017 - Apr 2017)

Paper of the month

Berlin Institute of Health, Berlin, Germany

(Mar 2017 - Mar 2017)

Keystone Scholarship

Keystone Symposia, Keystone, USA

(Apr 2016 - Apr 2016)

Honor Fell Travel Award

British Society for Cell Biology, UK

(Apr 2015 - Apr 2015)

Senior Scholarship

Robinson College, Cambridge, UK

(Oct 2011 - Oct 2011)

Prize for Natural Sciences

Robinson College, Cambridge, UK

(Aug 2009 - Aug 2009)

Posters and Talks

Complex multi-enhancer contacts captured by GAM, a ligation-free method for measuring chromatin topology.

Quantitative Genomics 2016, London, UK

(Jun 2016 - Jun 2016)

  • Selected 15-minute talk

Complex multi-enhancer contacts captured by GAM, a ligation-free method for measuring chromatin topology.

EMBO Nuclear Structure Meeting, Isle sur la Sorgue, France

(Oct 2015 - Oct 2015)

  • Selected 15-minute talk

GAM: A novel, ligation-free method for identifying chromatin interactions genome-wide

Keystone Symposium on Epigenomics, Keystone, USA

(Apr 2015 - Apr 2015)

  • Selected 15-minute talk

Capturing complex multi-enhancer contacts with Genome Architecture Mapping (GAM), a novel ligation-free method

London Chromatin Club, London, UK

(Apr 2015 - Apr 2015)

  • Selected 25-minute talk

Trans-splicing as a byproduct of the transcription of multiple genes at transcription factories

Quantitative Methods in Gene Regulation (IOP Conference), Cambridge, UK

(Dec 2013 - Dec 2013)

  • Selected 5-minute talk

Teaching

Personal Tutor

Private One-on-One Tuition, London

(Oct 2012 - Current)

  • Private tuition and exam preparation for undergraduate students in biology and genetics.

Demonstrator

Software Carpentry, London (Greenwich)

(Oct 2013 - Oct 2013)

  • Helping to teach students best practices for reproducible research at a Software Carpentry workshop in Greenwich.

Organization

Student Representative

Local Consultative Committee, MRC Clinical Sciences Centre

(Nov 2012 - Current)

  • Communicating student views and concerns to CSC administration

Secretary and Chair

Robinson College Students Association, Cambridge

(Dec 2009 - Dec 2011)

  • Chaired meetings of the RCSA
  • Led meetings of the RCSA executive and helped to formulate new policy

Education

PhD Systems Biology & Epigenetics

Imperial College - London /

Max Delbruck Centre - Berlin

Oct 2011 - Current

BA (Hons) and MSci in Natural Sciences

Robinson College - Cambridge

Sep 2007 - Jul 2011

Secondary Education

Bishop Wordsworth’s School - Salisbury

Sep 2001 - Jul 2007

Skills